Quercetin is the most researched flavonoid molecule and, in activity studies, it is the flavonoid with the greatest potential for therapeutic use.
Quercetin is a strong antioxidant, with many functions attributed to its antioxidant activity. For example, quercetin has been shown to inhibit oxidation of LDL cholesterol, and to spare vitamin E and glutathione.
Quercetin down regulates inflammatory processes by inhibiting the enzymes cyclo-oxygenase and lipoxygenase. In addition, quercetin blocks histamine synthesis and release by mast cells and basophils.
Cataract formation is partially due to the conversion of glucose to sorbitol, which is catalyzed by aldose reductase. Quercetin inhibits aldose reductase.
Quercetin supports the body’s immune response to many viruses, including herpes simplex, poliovirus, influenza, respiratory syncytial virus and HIV.
Quercetin exerts anti-proliferative effects on many cancer cell types including: breast, leukemia, colon, ovary, squamous cell, endometrial, gastric and non-small-cell lung.
Ingredients
Magnesium Ascorbate 20mg Quercetin Dihydrate 333mg Bromelain 100mg
References
1] Ogasawara H et al, Effect of selected flavonoids on histamine release (HR) and hydrogen peroxide (H2O2) generation by human leukocytes [abstract]. J Allergy Clin Immunol. 1985;75 (suppl):184. [2] Middleton E Jr. Effect of flavonoids on basophil histamine release and other secretory systems. Prog Clin Biol Res. 1986;213:493–506.] [3] Knekt P et al, Flavonoid intake and risk of chronic diseases. Am J Clin Nutr. 2002 Sep;76(3):560-8.] [4] Miller AL. The etiologies, pathophysiology, and alternative/complementary treatment of asthma. Altern Med Rev. 2001 Feb; 6(1):20-47. [5] Shoskes DA et al. Quercetin in men with category III chronic prostatitis: a preliminary prospective, double-blind, placebo-controlled trial. Urology. 1999;54:960–963.][6] Rodriguez LV et al. Treatment of interstitial cystitis with a quercetin containing compound: a preliminary, double-blind placebo control trial. Presented at: American Urological Association 2001 Annual Meeting; June 2–7, 2001; Anaheim, Calif][7] Constant J. Alcohol, ischemic heart disease, and the French paradox. Coron Artery Dis. 1997;8:645–649. [8] Hayek T et al, Reduced progression of atherosclerosis in apolipoprotein E-deficient mice following consumption of red wine, or its polyphenols quercetin or catechin, is associated with reduced susceptibility of LDL to oxidation and aggregation. Arterioscler Thromb Vasc Biol. 1997;17:2744–2752. [9] Frankel EN et al Inhibition of human LDL oxidation by resveratrol. Lancet. 1993;341:1103–1104. Alliangana DM. Effects of beta-carotene, flavonoid quercetin and quinacrine on cell proliferation and lipid peroxidation breakdown products in BHK-21 cells. East Afr MedJ. 1996;73:752–757. [10] Keli SO et al. Dietary flavonoids, antioxidant vitamins, and incidence of stroke: the Zupthen study. Arch Intern Med. 1996;156:637–642. [11] [Beretz, et al, “Role of cyclic AMP in the inhibition of human platelet aggregation by quercetin, a flavonoid that potentiates the effect of prostacyclin.” Biochemical Pharmacology 1981;31(22):3597-600.[12] Quercetin protects LDL from oxidation by lipid peroxides and transition metal ions. Oxidized LDL is absorbed by macrophages and arterial endothelial cells, eventually leading to plaque deposits in arterial walls. [13] AfanasÂ’ev, I.B. et. al., “Chelating and free radical scavenging mechanisms of inhibitory action of rutin and quercetin in lipid peroxidation.” Biochemical Pharmacology 1989;38(11):1763-69. [14] De Whalley, C.V., “Flavonoids inhibit the oxidative modification of low density lipoproteins by macrophages.” Biochemical Pharmacology 39(11):1743-50.][15] Balasubramanian S, Govindasamy S. Inhibitory effect of dietary flavonol quercetin on 7,12-dimethylbenz[a]anthracene- induced hamster buccal pouch carcinogenesis. Carcinogenesis. 1996;17:877–879. [16] Cross HJ et al. Effect of quercetin on the genotoxic potential of cisplatin. Int J Cancer. 1996;66:404–408. [17] Hoffman R et al. Enhanced anti-proliferative action of busulphan by quercetin on the human leukaemia cell line K562. Br J Cancer. 1989;59:347–348. [18] ElAttar TM et al. Modulating effect of resveratrol and quercetin on oral cancer cell growth and proliferation. Anticancer Drugs. 1999;10:187–193. [19] Yoshida M et al. Quercetin arrests human leukemic T-cells in late G1 phase of the cell cycle. Cancer Res. 1992;52:6676–6681. [20] Knekt P., Flavonoid intake and risk of chronic diseases. Am J Clin Nutr. 2002 Sep;76(3):560-8.] [21] Varma SD et al. Diabetic cataracts and flavonoids. Science. 1977;195:205–206] [22] Kaul TN et al. Antiviral effect of flavonoids on human viruses. J Med Virol. 1985;15:71–79. [23] Musci I, Pragai BM. Inhibition of virus multiplication and alteration of cyclic AMP level in cell cultures by flavonoids. Experientia. 1985;41:930–931.] [24] Choi JS. Enhanced diltiazem bioavailability after oral administration of diltiazem with quercetin to rabbits. Int J Pharm. 2005 Jun 13;297(1-2):1-8. [25] Hollma, P. et. al.,  “Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers.” Am. J. Clin. Nutr. 1995;62:1276-82.][25] Beretz, et al, “Role of cyclic AMP in the inhibition of human platelet aggregation by quercetin, a flavonoid that potentiates the effect of prostacyclin.” Biochemical Pharmacology 1981;31(22):3597-600. [26] Heinicke et al “Effect of bromelain (Ananase®) on human platelet aggregation. ”Experientia 1972;28(7):844] [27] Ebeler SE et al, Animal models and analytical approaches for understanding the relationships between wine and cancer. Drugs Exp Clin Res. 2005;31(1):19-27.[28] Xu J. Antiinflammatory constituents from the roots of Smilax bockii warb. Arch Pharm Res. 2005 Apr;28(4):395-9.[29] Chow JM, Quercetin, but not rutin and quercitrin, prevention of H(2)O(2)-induced apoptosis via anti-oxidant activity and heme oxygenase 1 gene expression in macrophages. Biochem Pharmacol. 2005 Jun 15;69(12): 1839-51.][30] Delporte C, Analgesic-antiinflammatory properties of Proustia pyrifolia. J Ethnopharmacol. 2005 May 13;99(1):119-24.[31] Akbas SH et al, The effect of quercetin on topotecan cytotoxicity in MCF-7 and MDA-MB 231 human breast cancer cells. J Surg Res. 2005 May 1;125(1):49-55. [A1] Davis JM, Murphy EA, Carmichael MD, Davis B. Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance.Am J Physiol Regul Integr Comp Physiol. 2009 Feb 11.
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