Product Info

Who needs Cardio Mag-lo-plex IITM? Anyone who has high blood pressure, angina (heart pains), cardiomyopathy (weak heart contractility), chronic muscle spasms or weakness, chronic fatigue, irregular heartbeats, diabetes, and/or chronic headaches may benefit from taking Cardio Mag-lo-plex IITM. In addition, anyone taking diuretics, for fluid retention or high blood pressure, is most likely to have a magnesium deficiency and may also benefit from a magnesium supplement. If a patient has been taking a high dose of calcium supplements, it is especially important to make sure that they are getting adequate amounts of magnesium. High doses of calcium can cause a deficiency of magnesium. Calcium is commonly prescribed in high doses for people who have or are at risk for osteoporosis. Patients who have not responded to conventional magnesium supplementation should consider switching to sustained-release magnesium such as Cardio Mag-lo-plex IITM to make sure they are receiving the full benefits of magnesium. Furthermore, patients taking cholesterol-lowering drugs may be at risk for developing a coenzyme Q10 deficiency, which can seriously impair the function of the heart muscle. Why a sustained-release formulation? Magnesium supplementation presents with the inconvenience that higher doses result in loose stools. Thus, before a significant therapeutic dosage level can be achieved, diarrhea usually occurs. In fact, large doses of magnesium have been shown to lead to magnesium deficiency because of the additional loss of magnesium into the loose stools. Up until now the only way to get larger doses of magnesium into the cells of the body has been to give magnesium intravenously or intramuscularly. The sustained-release magnesium in Cardio Mag-lo-plex IITM has been developed to address this unwanted side-effect of magnesium. Sustained-release magnesium allows for gradual dosing in the intestines during transit. Gradual dosing greatly enhances magnesium absorption into the blood stream while reducing the tendency to loose stool — both valuable advantages in the treatment of many diseases that require high dose magnesium supplementation. What about magnesium? Over 70% of the population in the U.S. fails to meet the USRDA for magnesium intake. Evidence indicates that the optimal intake for magnesium is probably more than twice the RDA. Magnesium is involved in over 2,000 biochemical reactions in the body! This makes magnesium an absolutely indispensable nutrient. Evidence has been mounting for many years that magnesium deficiency is one factor responsible for the number one cause of death in the U.S., heart disease. Magnesium is concentrated in the heart muscle over 20 times the level found in the blood! It is believed that magnesium deficiency predisposes people to high blood pressure, heart attacks, heart disease, strokes, cardiomyopathy (a weakening of the heart muscle) and chronic muscle spasms. Magnesium deficiency may also be involved in many other conditions including chronic migraine headaches, fatigue, asthma, constipation, PMS and toxemia of pregnancy. Where does magnesium function in the body? Magnesium is involved in thousands of reactions in the body. Mitochrondria, which are the power organelles of every cell in the body, depend upon magnesium for proper function. Without magnesium these power producers completely shut down. It is known that lead poisons these organelles by blocking the proper utilization of magnesium. Highly energetic tissues in the body like muscles, the heart, sperm, smooth muscles, etc., are most affected by a magnesium deficiency. Heart attack, which is still by far the number one killer in the U.S., is a condition in which not enough blood travels through the blood vessels of the heart due to spasm of the coronary vessels. Coronary vessels are composed largely of smooth muscle which have many mitochondria. A magnesium deficiency can not only trigger the initial coronary spasm, but can further worsen the spasm after the heart attack begins. In someone who has a lot of magnesium in the tissues of the heart muscle and arteries that supply the heart muscle, magnesium will dilate the vessels and increase blood flow into the tissues of the heart. It has been demonstrated that early administration of intravenous (IV) magnesium at the time of a heart attack will greatly increase the chances of survival. In fact, many hospitals around the world routinely give IV magnesium at the earliest onset of a suspected heart attack. This same phenomenon also happens during a stroke. Once there is bleeding into the brain, the vessels tend to spasm in response to the trauma. This spasm further reduces blood flow into the brain resulting in greater damage. Magnesium deficiency greatly contributes to this spasm. Additionally, a deficiency may also contribute to a potassium deficiency which has been linked to hypertension, a condition that affects over 50 million people in the U.S.! What are signs and symptoms of magnesium deficiency? A deficiency of magnesium results in fatigue, irritability, weakness, muscle spasms or tight muscles. In addition, a deficiency may lead to high blood pressure, heart problems, sugar cravings, insomnia or anxiety. The following is a list of conditions that magnesium may be used to treat: 1) constipation 2) neck and back tightness 3) headaches 4) diabetes 5) asthma 6) heart conditions such as angina, arrhythmias, congestive heart failure or weak heart 7) migraine headaches 8) high blood pressure 9) lead & chemotherapy toxicity 10)fatigue 11)osteoporosis 12)toxemia of pregnancy 13)dysmenorrhea (painful periods) Why haven’t I heard more about magnesium in the news? Magnesium is a rather inexpensive and simple mineral. It is very difficult to measure how much magnesium is in your tissues. Measuring magnesium levels in the blood does not give an accurate assessment of how much is in your tissues. A test called the ExatestTM, developed by Dr. Burton Silver, can measure intra-cellular tissue levels by looking at cells taken from under the tongue (www.exatest.com).

Ingredients

• Magnesium, 150 mg – Magnesium strengthens the heart muscle yet relaxes smooth muscle contractility in both peripheral and coronary vessels. In all muscle tissues the majority of magnesium is found in the mitochondria. Magnesium also affects the chemical balances between calcium, sodium and potassium electrolytes.
• Hawthorne (Crataegus oxycanthus), 100 mg – This botanical has many beneficial effects on the cardiovascular system. It strengthens the connective tissue of both the blood vessels and heart muscle. This benefit allows these structures to be more resilient to the pressures to which they are constantly being subjected. Hawthorne also relaxes the smooth muscle of the blood vessels enabling the heart to experience increased blood flow while peripheral vascular pressure is lowered. Hawthorne also strengthens the contractility of the cardiac muscle.
• Coenzyme Q10, 5 mg – This naturally occurring compound, also called ubiquinone, has profound effects on the heart. It concentrates in the mitochondria and is critical for the production of the high energy demands that allow the heart muscle to contract with regularity and precision. It also has a blood pressure lowering effect. In addition, it acts as a potent antioxidant and protects the delicate endothelial cells of the heart and blood vessels from oxidative damage.
• Vitamin E, 10 IU – This potent antioxidant has a long history of treating heart problems, particularly angina and heart failure. Its antioxidant properties protect the heart and blood vessels while increasing oxygen to the heart.
• Potassium, 99 mg – An important mineral that regulates the electrical activity and the rhythm of the heart. A deficiency of potassium has been linked to high blood pressure. (The High blood Pressure Solution by Dr. Moore) Potassium is essential for the storage of glycogen in muscles.
• Calcium, 15 mg – the most abundant mineral in the body, is essential for cell membrane transport and cell membrane stabilization. All muscle physiology, including the cardiac muscle tissue, is dependent on calcium for proper contractility and conductivity. Hypertension and congestive heart failure can benefit from the effects of calcium
• Chromium, 15 mcg – Chromium is involved with fat and cholesterol metabolism, and is useful in cholesterol lowering regimens. Chromium is vital to the regulation of blood sugar levels via the production of glucose tolerance factor. The integrity of the cardiovascular system is most sensitive to both cholesterol and glucose levels in the blood.
• One advantage of the sustained-release formulation is to provide increased bioavailability of the nutrients resulting in increased absorption and optimal tissue retention. A second advantage is to reduce the unwanted side-effects of the hygroscopic nature of magnesium.

References

Rasmussen, HS, et al Intravenous magnesium in acute myocardial infarction Lancet 1:234, 1986. Webster, P. & Dyckner, T. Intracellular electrolytes in cardiac failure Acta Med Scand 707:33-36, 1986. Mauskop A. & Altura B. M. Role of magnesium in the pathogenesis and treatment of migraines Clin Neurosci 5(1): 24-27, 1988. Ramadan N. M., et al Low Brain Magnesium in Migraine Headache 29:416-419, 1989. Rude, Robert. Magnesium deficiency and diabetes mellitus Postgraduate Medicine, Vol 29 #5, October 1992. Paolisso G. & Barbagallo, M. Hypertension, diabetes mellitus, and insulin resistance: the role of intracellular magnesium Am J Hypertension 10(3):346-55, 1997. Resnick L. M., Gupta R. K., Laragh, J. H. Intracellular free magnesium in erythrocytes of essential hypertension: relation to blood pressure and serum divalent cations Proc Natl Acad Sci USA, 81(20) 6511-5, 1984. Kawano Y., Matsuoka H., Takishita S., Omae T. Effects of Magnesium Supplementation in Hypertensive Patients Hypertension Vol 32, Aug, 1998. Rude, Robert. Magnesium deficiency and diabetes mellitus Postgraduate Medicine Vol 29 #5, October 1992. Witteman, J. C., et al Reduction of blood pressure with oral magnesium supplementation in women with mild to moderate hypertension AJCN Jul; 60 (1):129-35, 1994. Corica F., et al Effects of oral magnesium supplementation on plasma lipid concentrations in patients with NIDDM Magnesium Research 7: 1; 43-47, 1994.